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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE
All Species:
14.55
Human Site:
T1188
Identified Species:
35.56
UniProt:
Q07864
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07864
NP_006222.2
2286
261518
T1188
K
K
I
S
E
L
F
T
L
E
G
R
R
Q
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543348
2273
260734
V1181
K
K
I
S
E
L
F
V
L
E
G
R
R
Q
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVF7
2283
262009
V1188
K
K
I
S
E
L
F
V
L
E
G
K
R
Q
I
Rat
Rattus norvegicus
NP_001100622
1515
174729
L520
S
K
E
E
G
K
K
L
K
K
R
Y
A
V
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233985
2277
260654
T1182
K
K
I
N
E
L
F
T
S
E
G
K
R
Q
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121995
2284
262166
T1187
K
K
I
S
E
L
F
T
S
E
G
K
R
Q
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524462
2236
256683
T1189
R
R
I
N
E
M
F
T
S
R
P
K
P
K
P
Honey Bee
Apis mellifera
XP_393171
2183
252634
S1185
R
K
I
T
D
V
F
S
V
I
H
K
D
K
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002328167
2221
254636
N1158
R
K
L
V
D
I
F
N
L
R
S
R
D
D
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P21951
2222
255653
K1190
K
I
A
T
K
E
D
K
F
K
Q
T
S
L
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
90.7
N.A.
90.5
60.7
N.A.
N.A.
83.7
N.A.
80
N.A.
55.2
54.6
N.A.
N.A.
Protein Similarity:
100
N.A.
N.A.
94.6
N.A.
95
63.5
N.A.
N.A.
92
N.A.
90.2
N.A.
71.9
71.5
N.A.
N.A.
P-Site Identity:
100
N.A.
N.A.
93.3
N.A.
80
6.6
N.A.
N.A.
73.3
N.A.
86.6
N.A.
26.6
20
N.A.
N.A.
P-Site Similarity:
100
N.A.
N.A.
93.3
N.A.
93.3
13.3
N.A.
N.A.
86.6
N.A.
93.3
N.A.
66.6
73.3
N.A.
N.A.
Percent
Protein Identity:
43.5
N.A.
N.A.
N.A.
40.5
N.A.
Protein Similarity:
62.7
N.A.
N.A.
N.A.
60.1
N.A.
P-Site Identity:
26.6
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
60
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
20
0
10
0
0
0
0
0
20
10
0
% D
% Glu:
0
0
10
10
60
10
0
0
0
50
0
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
80
0
10
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
10
0
0
0
0
0
50
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% H
% Ile:
0
10
70
0
0
10
0
0
0
10
0
0
0
0
10
% I
% Lys:
60
80
0
0
10
10
10
10
10
20
0
50
0
20
0
% K
% Leu:
0
0
10
0
0
50
0
10
40
0
0
0
0
10
10
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
20
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
20
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
10
0
0
50
0
% Q
% Arg:
30
10
0
0
0
0
0
0
0
20
10
30
50
0
0
% R
% Ser:
10
0
0
40
0
0
0
10
30
0
10
0
10
0
0
% S
% Thr:
0
0
0
20
0
0
0
40
0
0
0
10
0
0
10
% T
% Val:
0
0
0
10
0
10
0
20
10
0
0
0
0
10
30
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _